Total synthesis of dehaloperophoramidine using a highly diastereoselective Hosomi-Sakurai reaction.
نویسندگان
چکیده
The synthesis of dehaloperophoramidine, a non-halogenated derivative of the marine natural product perophoramidine, and its biological activity towards HCT116, HT29 and LoVo colorectal carcinoma cells is reported. A [3,3]-Claisen rearrangement and an epoxide opening/allylsilylation reaction installed the contiguous all-carbon quaternary stereocentres with the required relative stereochemistry.
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عنوان ژورنال:
- Chemical communications
دوره 52 71 شماره
صفحات -
تاریخ انتشار 2016